Usai separuh makhluk di alam semesta dilenyapkan oleh Thanos di Avengers: Infinity War, para anggota Avengers yang tersisa bersama sekutu mereka harus bersatu kembali demi memulihkan keadaan, dengan sebuah perlawanan terakhir.

After half of all life in the universe was killed due to the actions of Thanos in Avengers: Infinity War, the remaining Avengers and their allies must reassemble to revert those actions in one final stand.