House of Gucci terinspirasi oleh keluarga di belakang rumah mode Italia Gucci. Ketika Patrizia Reggiani (Lady Gaga), orang luar yang sederhana, menikah dengan keluarga Gucci, ambisinya yang tak terkendali mulai mengurai warisan keluarga dan memicu pengkhianatan, balas dendam, dan akhirnya ... pembunuhan.

House of Gucci is inspired by the family empire behind the Italian fashion house of Gucci. When Patrizia Reggiani (Lady Gaga), an outsider from humble beginnings, marries into the Gucci family, her unbridled ambition begins to unravel the family legacy and triggers a reckless spiral of betrayal, decadence, revenge, and ultimately...murder.